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Comparative Study
. 1992 Dec;66(12):7517-21.
doi: 10.1128/JVI.66.12.7517-7521.1992.

An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1

R Collman  1 , J W Balliet, S A Gregory, H Friedman, D L Kolson, N Nathanson, A Srinivasan
Affiliations
Comparative Study

An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1

R Collman et al. J Virol. 1992 Dec.

Abstract

We isolated and molecularly cloned a human immunodeficiency virus type 1 (HIV-1) strain (89.6) which is unusual because it is both macrophage-tropic and extremely cytopathic in lymphocytes. Moreover, this is the first well-characterized infectious molecularly cloned macrophage-tropic HIV-1 strain derived from peripheral blood. HIV-1 89.6 differs markedly from other macrophage-tropic isolates within the envelope V3 region, which is important in determining cell tropism and cytopathicity. HIV-1 89.6 may thus represent a transitional isolate between noncytopathic macrophage-tropic viruses and cytopathic lymphocyte-tropic viruses.

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References

    1. Proc Natl Acad Sci U S A. 1989 Nov;86(21):8575-9 - PubMed
    1. J Exp Med. 1989 Oct 1;170(4):1149-63 - PubMed
    1. J Mol Biol. 1970 Mar;48(3):443-53 - PubMed
    1. J Virol. 1992 Apr;66(4):2577-82 - PubMed
    1. J Virol. 1992 May;66(5):3183-7 - PubMed

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