doi: 10.1128/JVI.66.12.7549-7554.1992.
Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5
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- PMID: 1433530
- PMCID: PMC240467
- DOI: 10.1128/JVI.66.12.7549-7554.1992
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Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5
J Virol.
1992 Dec.
Abstract
Processing of dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5 could be mediated by the catalytically active NS3 protease domain and NS2B in trans at the dibasic sites NS3-NS4A and NS4B-NS5. Subcellular localization of the unprocessed precursor NS3-NS4A-NS4B-NS5 showed that it was confined to a distinct subcellular organelle in the cytoplasm, which was distinct from the distribution of the mature NS5.
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