[Function, molecular structure and gene expression regulation of nerve growth factor]

Abstract

Nerve growth factor (NGF) is the initially discovered and best characterized target-derived neurotrophic factor. The NGF gene family includes NGF, brain-derived neurotrophic factor (BDNF), neurotrophin (NT)-3, NT-4, and NT-5. The members of this family can interact with the members of trk family of receptor-like protein-tyrosine kinases (trk, trk B and trk C), suggesting that the different trk protein serves as receptor subunits for the different neurotrophins. Meanwhile, some recent reports have shown that exogenous administration of NGF itself or a stimulator of NGF synthesis to damaged neurons have beneficial effects. These findings open the possibility of new therapy for nervous diseases, such as Alzheimer's disease.