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. 1965 Mar;94(3):773-7.
doi: 10.1042/bj0940773.

THE INHIBITION OF TWO STEROID-ACTIVATED NICOTINAMIDE-ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASES BY FOLIC ACID AND FOLIC ACID ANTIMETABOLITES

W I MAINWARING, D C WILLIAMS

THE INHIBITION OF TWO STEROID-ACTIVATED NICOTINAMIDE-ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASES BY FOLIC ACID AND FOLIC ACID ANTIMETABOLITES

W I MAINWARING et al. Biochem J. 1965 Mar.

Abstract

1. It was found that steroid-mediated nicotinamide-adenine dinucleotide (phosphate) transhydrogenases can be inhibited in vitro by folic acid and its antimetabolites. The most potent inhibitor was methotrexate, a drug with a high therapeutic index against experimental cancer. 2. The inhibitions produced by a combination of folic acid and the analogues were additive, as were those between the folic acid compounds and antagonistic steroid hormones.

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