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Comparative Study
. 1977 Jan 31;51(2):181-3.
doi: 10.1007/BF00431737.

Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats

H Y Meltzer, S M Paul, V S Fang
Comparative Study

Effect of flupenthixol and butaclamol isomers on prolactin secretion in rats

H Y Meltzer et al. Psychopharmacology (Berl). .

Abstract

Cis (alpha)-flupenthixol and (+)-butaclamol are effective anti-psychotic agents but trans (beta)-flupenthixol and (-)-butaclamol are not. alpha-Flupenthixol was found to be 245 times more active in elevating rat plasma prolactin than the beta-isomer. The discrepancy between (+)-butaclamol and (-)-butaclamol was even greater. These results support the hypothesis that the dopamine receptors that mediate the effects of dopamine on prolactin secretion are similar to those that mediate the anti-psychotic effect of neuroleptic drugs.

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References

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