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. 1992 Oct 29;359(6398):794-801.
doi: 10.1038/359794a0.

A second-generation linkage map of the human genome

J Weissenbach  1 , G Gyapay, C Dib, A Vignal, J Morissette, P Millasseau, G Vaysseix, M Lathrop
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A second-generation linkage map of the human genome

J Weissenbach et al. Nature. .

Abstract

A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to approximately 90% of the estimated length of the human genome.

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