doi: 10.1038/359801a0.
Crystal structure of staphylococcal enterotoxin B, a superantigen
Affiliations
- PMID: 1436058
- DOI: 10.1038/359801a0
Item in Clipboard
Crystal structure of staphylococcal enterotoxin B, a superantigen
Nature.
.
Abstract
The three-dimensional structure of staphylococcal enterotoxin B, which is both a toxin and a super-antigen, has been determined to a resolution of 2.5 A. The unusual main-chain fold containing two domains may represent a general motif adopted by all staphylococcal enterotoxins. The T-cell receptor binding site encompasses a shallow cavity formed by both domains. The MHCII molecule binds to an adjacent site. Another cavity with possible biological activity was also identified.
Similar articles
-
The crystal structure of staphylococcal enterotoxin H: implications for binding properties to MHC class II and TcR molecules.J Mol Biol. 2000 Sep 22;302(3):527-37. doi: 10.1006/jmbi.2000.4093. J Mol Biol. 2000. PMID: 10986116
-
Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1.Nature. 1994 Jan 6;367(6458):94-7. doi: 10.1038/367094a0. Nature. 1994. PMID: 8107781
-
Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen.Nature. 1994 Apr 21;368(6473):711-8. doi: 10.1038/368711a0. Nature. 1994. PMID: 8152483
-
Staphylococcal enterotoxins B and C. Structural requirements for superantigenic and entertoxigenic activities.Prep Biochem Biotechnol. 1997 May-Aug;27(2-3):79-110. doi: 10.1080/10826069708000072. Prep Biochem Biotechnol. 1997. PMID: 9292922 Review. No abstract available.
-
Staphylococcal enterotoxins A, D, and E. Structure and function, including mechanism of T-cell superantigenicity.Prep Biochem Biotechnol. 1997 May-Aug;27(2-3):111-41. doi: 10.1080/10826069708000073. Prep Biochem Biotechnol. 1997. PMID: 9292923 Review. No abstract available.
Cited by
-
Peptide antagonists of superantigen toxins.Mol Divers. 2004;8(2):113-20. doi: 10.1023/b:modi.0000025654.04427.44. Mol Divers. 2004. PMID: 15209162
-
Mutational analysis of superantigen activity responsible for the induction of skin erythema by streptococcal pyrogenic exotoxin C.Infect Immun. 1998 Oct;66(10):5020-6. doi: 10.1128/IAI.66.10.5020-5026.1998. Infect Immun. 1998. PMID: 9746612 Free PMC article.
-
Superantigens in demyelinating disease.Springer Semin Immunopathol. 1996;18(1):51-6. doi: 10.1007/BF00792608. Springer Semin Immunopathol. 1996. PMID: 8984679 Review. No abstract available.
-
Oral immunization with Lactococcus lactis secreting attenuated recombinant staphylococcal enterotoxin B induces a protective immune response in a murine model.Microb Cell Fact. 2013 Apr 5;12:32. doi: 10.1186/1475-2859-12-32. Microb Cell Fact. 2013. PMID: 23561053 Free PMC article.
-
Immune response to staphylococcal superantigens.Immunol Res. 1999;20(2):163-73. doi: 10.1007/BF02786471. Immunol Res. 1999. PMID: 10580640 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
