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. 1992 Aug 31;143(1-2):35-8.
doi: 10.1016/0304-3940(92)90227-x.

Glial fibrillary tangles with straight tubules in the brains of patients with progressive supranuclear palsy

M Nishimura  1 , Y Namba, K Ikeda, M Oda
Affiliations

Glial fibrillary tangles with straight tubules in the brains of patients with progressive supranuclear palsy

M Nishimura et al. Neurosci Lett. .

Abstract

A recent report has described the appearance of silver positive, tau-immunoreactive astrocytes in the brains of patients with progressive supranuclear palsy (PSP) (Neurosci. Lett., 135 (1992) 99-102). In this study we confirmed this finding in two cases of PSP by using Bodian silver staining and immunohistochemistry with antibody to human tau protein. By electron microscopy we demonstrated that fibrillary masses present in these unique astrocytes were made up of straight tubules that were indistinguishable from those of neurofibrillary tangles of PSP. The term 'glial fibrillary tangle' was proposed for these structures.

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