doi: 10.1084/jem.101.6.639.
A tissue factor influencing succinic dehydrogenase activity in tuberculous guinea pigs
- PMID: 14367685
- PMCID: PMC2136487
- DOI: 10.1084/jem.101.6.639
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A tissue factor influencing succinic dehydrogenase activity in tuberculous guinea pigs
J Exp Med.
.
Abstract
The alterations in succinic dehydrogenase activity during the course of infection with Mycobacterium tuberculosis strains H37Rv and BCG, as well as with dead bacilli, has been described. A tissue factor has been described which is prepared from normal bovine kidney and will restore enzyme activity in vitro. This factor is prepared by chromatographic analysis and contains a nucleotide with an ultraviolet absorption maxima at 250 mmicro (pH 3) and a free sulfhydryl group. The role of this factor in the response to tuberculosis is discussed.
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