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Review
. 1992 Oct 16;14(5):297-304.
doi: 10.1007/BF01977617.

Didanosine, a new antiretroviral drug. A review

R M Franssen  1 , P L Meenhorst, C H Koks, J H Beijnen
Affiliations
Review

Didanosine, a new antiretroviral drug. A review

R M Franssen et al. Pharm Weekbl Sci. .

Abstract

In this article the literature about didanosine, an antiretroviral drug, is reviewed. The mechanism of action, biochemical pharmacology, pharmacokinetics, and clinical results of phase-I trials are discussed. Serious adverse effects such as pancreatitis and peripheral neuropathy have occurred in these trials. An antiretroviral effect was observed in terms of an increase in CD4+ lymphocytes and a decrease in p24 antigen levels in HIV-infected individuals. Didanosine seems to be a promising drug against HIV infection, but knowledge about its clinical efficacy is scanty.

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