[Mucus models for investigation of intestinal absorption mechanisms. 2. Mechanisms of drug interactions with intestinal mucus]
[Article in
German]
Affiliations
- PMID: 1438513
Item in Clipboard
[Mucus models for investigation of intestinal absorption mechanisms. 2. Mechanisms of drug interactions with intestinal mucus]
[Article in
German]
Pharmazie.
1992 Aug.
Abstract
Using in vitro models previously described [1] mucus retention and mucus diffusion of polar and non-polar drugs were measured. It could be shown that drug interaction with pig intestinal mucus was based on non-specific binding. The pH-dependence of retention by mucus does not confirm electrostatic interaction of drugs with mucus but favour drug distribution to hydrophobic areas within the mucus. High lipophilicity and retention by mucus correlate with low diffusion of drugs through mucus.
Similar articles
-
[Mucus models for investigation of intestinal absorption mechanisms. 4. Comparison of mucus models with absorption models in vivo and in situ for prediction of intestinal drug absorption].Pharmazie. 1992 Oct;47(10):787-91. Pharmazie. 1992. PMID: 1480659 German.
-
[Mucus models for investigation of intestinal absorption mechanisms. 3. A mathematical simulation model of drug diffusion through enteral mucus].Pharmazie. 1992 Sep;47(9):699-704. Pharmazie. 1992. PMID: 1475317 German.
-
Regulation of metal absorption in the gastrointestinal tract.Gut. 1996 Nov;39(5):625-8. doi: 10.1136/gut.39.5.625. Gut. 1996. PMID: 9026473 Free PMC article. No abstract available.
-
[Mechanisms of pharmacokinetic drug interactions. 2: Interaction mechanisms during absorption].Pharmazie. 1984 Feb;39(2):129-36. Pharmazie. 1984. PMID: 6371841 Review. German. No abstract available.
-
The hydrophobic barrier properties of gastrointestinal mucus.Annu Rev Physiol. 1995;57:565-83. doi: 10.1146/annurev.ph.57.030195.003025. Annu Rev Physiol. 1995. PMID: 7778878 Review.
Cited by
-
Reduced Salivary Mucin Binding and Glycosylation in Older Adults Influences Taste in an In Vitro Cell Model.Nutrients. 2019 Sep 24;11(10):2280. doi: 10.3390/nu11102280. Nutrients. 2019. PMID: 31554163 Free PMC article.
-
Interaction of bile salt and phospholipids with bovine submaxillary mucin.Pharm Res. 2001 Jan;18(1):45-53. doi: 10.1023/a:1011022626030. Pharm Res. 2001. PMID: 11336352
-
Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo.Pharm Res. 1996 Nov;13(11):1668-72. doi: 10.1023/a:1016488623022. Pharm Res. 1996. PMID: 8956332
-
Drug, meal and formulation interactions influencing drug absorption after oral administration. Clinical implications.Clin Pharmacokinet. 1999 Mar;36(3):233-54. doi: 10.2165/00003088-199936030-00004. Clin Pharmacokinet. 1999. PMID: 10223170 Review.
-
Physicochemical properties of mucus and their impact on transmucosal drug delivery.Int J Pharm. 2017 Oct 30;532(1):555-572. doi: 10.1016/j.ijpharm.2017.09.018. Epub 2017 Sep 14. Int J Pharm. 2017. PMID: 28917986 Free PMC article. Review.