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Clinical Trial
. 1992 May-Jul;17(2-3):223-9.
doi: 10.1016/0306-4530(92)90061-b.

A double-blind, placebo-controlled study of the effect of imipramine on TRH-induced urinary urgency in healthy men

N E Alessi  1 , C D Knight, J T Bergs, S J Eisner
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Free article
Clinical Trial

A double-blind, placebo-controlled study of the effect of imipramine on TRH-induced urinary urgency in healthy men

N E Alessi et al. Psychoneuroendocrinology. 1992 May-Jul.
Free article

Abstract

We studied the effect of imipramine (IMI) on thyroid releasing hormone (TRH)-induced urinary urgency as a way of investigating the mechanism of the beneficial effect of IMI on enuresis. In a double-blind study, 12 normal, healthy men between 21 and 39 yr of age ranked their urge to urinate at 30-sec intervals following IV injection of TRH (500 micrograms) or saline. The subjects then were randomly assigned to either IMI (1 mg/kg) or placebo groups for 10 days, and the procedure was repeated. Compared to saline, TRH produced a significant elevation in urinary urgency in all subjects. IMI did not significantly blunt TRH-induced urinary urgency. Thus, the mechanism by which IMI affects enuresis is likely not mediated at the level of the urinary urgency induced by TRH.

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