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Review
. 1992;12(4):121-7.
doi: 10.1007/BF00274931.

The pathogenetic aspects of spondyloarthropathies from the point of view of HLA-B27

H Kellner  1 , D Yu
Affiliations
Review

The pathogenetic aspects of spondyloarthropathies from the point of view of HLA-B27

H Kellner et al. Rheumatol Int. 1992.

Abstract

The association of HLA-B27 and seronegative spondyloarthropathies, especially ankylosing spondylitis has been known for almost two decades. The spontaneous development of spondyloarthropathy like joint disease in HLA-B27 transgenic rats verifies the suspicion that the HLA-B27 antigens are directly responsible for disease development. With the recently revealed crystal structure of HLA-B27 and understanding of the class I molecule in general, a new hypothesis can be formulated based on the assumption that the pathogenesis of these diseases is a subversion of the physiological function.

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References

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