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. 1977 Mar 11;195(4282):982, 989-90.
doi: 10.1126/science.14399.

Possible cyclic nucleotide regulation of calcium mediating myocardial contraction

A Schwartz, M L Endman, E G Ezrailson, D C Lehotay, G Leyey

Possible cyclic nucleotide regulation of calcium mediating myocardial contraction

A Schwartz et al. Science. .

Abstract

An inhibitor of adenylate and guanylate cyclases was tested on strips of left atria from rabbits. Effects of catecholamines (cardiotonic) and of acetylcholine (cardiodepressive) were blocked, and positive force-frequency was converted to negative. Ouabain produced only contracture without positive inotropy. The cardiotonic effect of increased calcium remained. Data suggest that cyclic nucleotides modulate calcium associated with these stimuli.

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