Variations in the length of S-phase related to the time cells are blocked at the G1-S interface
- PMID: 144048
- DOI: 10.1007/BF00292940
Variations in the length of S-phase related to the time cells are blocked at the G1-S interface
Abstract
The inhibition of DNA synthesis with hydroxyurea or 5-fluorode-oxyuridine decreases the duration of S-phase of synchronously growing Chinese hamster cultures. - The observed drug effects are discussed in relation to an alteration of programmed DNA replication.
Similar articles
-
Hydroxyurea does not prevent synchronized G1 chinese hamster cells from entering the DNA synthetic period.Biochem Biophys Res Commun. 1976 Mar 8;69(1):212-7. doi: 10.1016/s0006-291x(76)80294-x. Biochem Biophys Res Commun. 1976. PMID: 1259759 No abstract available.
-
Evaluation of S phase synchronization by analysis of DNA replication in 5-bromodeoxyuridine.Exp Cell Res. 1973 Nov;82(1):137-42. doi: 10.1016/0014-4827(73)90255-3. Exp Cell Res. 1973. PMID: 4270895 No abstract available.
-
Does hydroxyurea inhibit DNA replication in mouse cells by more than one mechanism?Mol Cell Biol. 1983 Mar;3(3):297-304. doi: 10.1128/mcb.3.3.297-304.1983. Mol Cell Biol. 1983. PMID: 6221189 Free PMC article.
-
Sequence programming of DNA replication over the S phase of Chinese hamster cells.Exp Cell Res. 1977 Jan;104(1):47-54. doi: 10.1016/0014-4827(77)90067-2. Exp Cell Res. 1977. PMID: 137816 No abstract available.
-
Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation.Mutat Res. 1974 May;23(2):197-212. doi: 10.1016/0027-5107(74)90140-7. Mutat Res. 1974. PMID: 4275776 Review. No abstract available.
Cited by
-
Two phases of DNA replication in human cells.Chromosoma. 1980;76(1):101-10. doi: 10.1007/BF00292230. Chromosoma. 1980. PMID: 6987046
-
Pattern of chromosomal replication in synchronized lymphocytes. I. Evaluation and application of methotrexate block.Hum Genet. 1980;54(1):47-53. doi: 10.1007/BF00279048. Hum Genet. 1980. PMID: 6993339
-
cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication.EMBO J. 1992 Jun;11(6):2189-99. doi: 10.1002/j.1460-2075.1992.tb05278.x. EMBO J. 1992. PMID: 1318195 Free PMC article.
-
BrdU-Hoechst-Giemsa analysis of DNA replication in synchronized lymphocyte cultures. Study of human X and Y chromosomes.Chromosoma. 1982;85(4):553-69. doi: 10.1007/BF00327350. Chromosoma. 1982. PMID: 6181944
-
Single-stranded molecules in DNA preparations from cultured mammalian cells at different moments of cell cycle.Chromosoma. 1981;82(3):377-84. doi: 10.1007/BF00285763. Chromosoma. 1981. PMID: 7227043