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. 1992 Jul-Aug;86(4):446-7.
doi: 10.1016/0035-9203(92)90264-d.

Short-course treatment of typhoid fever with ciprofloxacin in south India

S Meskin  1 , M S Jacob, R Macaden, J S Keystone, P E Kozarsky, A N Ramachadran, B Metchock
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Short-course treatment of typhoid fever with ciprofloxacin in south India

S Meskin et al. Trans R Soc Trop Med Hyg. 1992 Jul-Aug.

Abstract

This study assessed the performance of short-course ciprofloxacin for the treatment of 34 adult patients with culture-positive typhoid fever. Patients received ciprofloxacin, 750 mg orally twice daily for 7 d. Measurement of response was based upon time from initial treatment to fever lysis, to afebrile state, and to symptom resolution. Ciprofloxacin-treated patients defervesced in a mean of 3.21 d (+/- 0.56), with stabilization of temperature in 4.0 +/- 0.73 d. After 90 d follow-up, no relapse or carrier was identified. Side effects during therapy were minimal.

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