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. 1959 Dec 11;130(3389):1653-4.
doi: 10.1126/science.130.3389.1653.

Stimulation of amino acid transport in isolated diaphragm by growth hormone added in vitro

J L KOSTYO, J HOTCHKISS, E KNOBIL

Stimulation of amino acid transport in isolated diaphragm by growth hormone added in vitro

J L KOSTYO et al. Science. .

Abstract

The influence of the pituitary on the transport of alpha-aminoisobutyric acid-1-C(14) into the cells of isolated rat diaphragm was investigated. Hypophysectomy results in a lower-than-normal rate of alpha-aminoisobutyric acid-1-C(14) penetration into muscle. Adding either simian or bovine growth hormone preparations to the incubation medium in concentrations of 2.5 to 25 microg/ml of medium resulted in a doubling of the alpha-aminoisobutyric acid-l-C(14) penetration rate. The stimulatory effect was minimized when the hormone concentration was reduced to 0.25 microg/ml of medium.

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