[The cialit-conserved trachea homograft (author's transl)]

Abstract

After all techniques for reconstruction of tracheal segments with trachea-homografts, known from the literature, have failed to show satisfactory functional results, we have carried out further experiments concerning this subject. Our main interest was focused on the following topics: 1. the regeneration pattern of the respiratory epithelium in the trachea, 2. possibilities of the conservation of trachea-transplants, 3. the behaviour of the receptor area against trachea homografts. We found, that in correspondence with clinical observations, even large circumferencial defected epithelial areas in the mucous layer of the trachea have been regenerated in a form of new mucous membrane which showed no morphological difference from normal structure. Segments of trachea can be preserved in Cialit solution. Prefixation in formaldehydsaline fixative improves the preservation of the tissue structure. Homografts obtained in the above described technique could almost always be made to heal, either directly in the trachea or in the subcutaneous tissue of the recipient-animals. The behaviour of the cartilage and the epithelium is demonstrated by histological methods as well as by scanning electronmicroscopy.