doi: 10.1016/0091-3057(77)90204-0.
Serotonergic basis of reward in median raphé of the rat
- PMID: 144276
- DOI: 10.1016/0091-3057(77)90204-0
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Serotonergic basis of reward in median raphé of the rat
Pharmacol Biochem Behav.
1977 Aug.
Abstract
Rats were trained to self-stimulate simultaneously in the ventromedian tegmentum (VMT) and the median raphe (MR) by pressing two independent bars. Bar-pressing rates for VMT self-stimulation (SS) were increased following methamphetamine and decreased following alpha-methyl-para-tyrosine while no appreciable effects were observed on SS in the MR. On the other hand, MR SS was specifically decreased following para-chlorophenylalanine. The above results taken together support the hypothesis that SS in the MR is due to the stimulation of serotonergic neuronal elements.
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