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. 1959 Nov;43(2):445-53.
doi: 10.1085/jgp.43.2.445.

The catabolism of plasma albumin in the rabbit: its rate and regulation

E B REEVE, J E ROBERTS

The catabolism of plasma albumin in the rabbit: its rate and regulation

E B REEVE et al. J Gen Physiol. 1959 Nov.

Abstract

From I(131)-albumin studies and previously defined mathematical formulations, rates of breakdown were estimated for native plasma albumin in rabbits. These rates of catabolism per unit weight of animal were remarkably constant and were independent of variations in the steady state values of albumin concentration in the plasma. These results imply that, at least between animals, the breakdown of plasma albumin follows a kinetic process of approximately zero order. It seems plausible that the process operates similarly in individual animals, and hence that albumin is maintained at normal steady state levels in the healthy animal primarily by means of a regulated rate of synthesis.

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References

    1. Fed Proc. 1955 Sep;14(3):707-16 - PubMed
    1. J Clin Invest. 1957 Mar;36(3):422-8 - PubMed
    1. Biochem J. 1957 Jun;66(2):255-64 - PubMed
    1. Ann N Y Acad Sci. 1957 Aug 30;70(1):122-36 - PubMed
    1. J Biol Chem. 1958 Mar;231(1):111-6 - PubMed