Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Oct;36(10):2328-30.
doi: 10.1128/AAC.36.10.2328.

Low-dose trimethoprim-sulfamethoxazole alone and in association with zidovudine for prevention and treatment of murine Pneumocystis carinii pneumonia

M Brun-Pascaud  1 , P M Girard, J J Pocidalo
Affiliations

Low-dose trimethoprim-sulfamethoxazole alone and in association with zidovudine for prevention and treatment of murine Pneumocystis carinii pneumonia

M Brun-Pascaud et al. Antimicrob Agents Chemother. 1992 Oct.

Abstract

Low-dose trimethoprim-sulfamethoxazole (TMP-SMX) alone was found to be as effective as low-dose TMP-SMX plus zidovudine and standard-dose TMP-SMX alone in preventing and treating Pneumocystis carinii pneumonia (PCP) in an immunosuppressed-rat model. Zidovudine alone had no preventive or curative effect on PCP. We conclude that the initially reported reduced incidence of PCP in human immunodeficiency virus-infected patients treated with zidovudine alone is not due to anti-P. carinii activity of zidovudine. Furthermore, the clinical efficacy of low-dose TMP-SMX for the prevention and treatment of PCP should be further investigated.

PubMed Disclaimer

References

    1. Antiviral Res. 1991 Sep;16(2):163-71 - PubMed
    1. Lancet. 1991 Feb 23;337(8739):468-71 - PubMed
    1. J Infect Dis. 1991 Feb;163(2):415-6 - PubMed
    1. J Acquir Immune Defic Syndr. 1991;4(5):532-7 - PubMed
    1. JAMA. 1988 Feb 26;259(8):1185-9 - PubMed

MeSH terms

Substances

LinkOut - more resources