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. 1992 Oct;36(10):2342-5.
doi: 10.1128/AAC.36.10.2342.

Bactericidal activity of ramoplanin against antibiotic-resistant enterococci

C C Johnson  1 , S Taylor, P Pitsakis, P May, M E Levison
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Bactericidal activity of ramoplanin against antibiotic-resistant enterococci

C C Johnson et al. Antimicrob Agents Chemother. 1992 Oct.

Abstract

Ramoplanin, a new lipoglycodepsipeptide antibiotic, was uniformly active against 65 strains of enterococci, including strains highly resistant to vancomycin, penicillin G, and gentamicin. MBCs were usually within a fourfold dilution of the MICs. In time-kill studies, ramoplanin alone demonstrated dose-dependent bactericidal activity against enterococcal strains that resisted killing by vancomycin or penicillin in combination with gentamicin.

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