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. 1977 Dec;37(12):4529-31.

Inhibition of lymphocyte transformation by disrupted murine oncornavirus

A K Fowler, D R Twardzik, C D Reed, O S Weislow, A Hellman
  • PMID: 144563

Inhibition of lymphocyte transformation by disrupted murine oncornavirus

A K Fowler et al. Cancer Res. 1977 Dec.

Abstract

Freeze-thaw preparations of banded Rauscher murine leukemia virus markedly suppressed the in vitro cellular-mediated blastogenic response of murine splenic lymphocytes to phytohemagglutinin-P and to allogeneic cells in two-way mixed-leukocyte reaction. Suppression was shown not to be due to cytotoxicity or to virus-mitogen binding. It is suggested that a virion envelope component interferes with cellular-mediated immunity by altering cell recognition sites.

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