Tumor-specific antigens of mouse tumors

Abstract

This article reviews the serological analysis of cell surface antigens of chemically induced sarcomas of murine origin. This analysis, which was aimed at molecular characterization of the highly restricted tumor specific transplantation antigens of sarcomas, led to the initial biochemical identification and characterization of p53. The results of this early study clearly pointed to p53 as playing a key role in cellular proliferation and transformation. Current research of the tumor-specific or -associated antigens of chemically-induced sarcomas and melanomas of murine origin is also discussed.