doi: 10.1016/S0940-2993(11)80229-0.
Effects of dipentylnitrosamine (DPNA) on the respiratory tract of rats
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- PMID: 1446157
- DOI: 10.1016/S0940-2993(11)80229-0
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Effects of dipentylnitrosamine (DPNA) on the respiratory tract of rats
Exp Toxicol Pathol.
1992 Sep.
Abstract
Wistar rats (40 males and 40 females), treated over a period of 25 weeks with subcutaneous injections of dipentylnitrosamine (DPNA) at doses of 0, 62.5, 125 and 250 mg/kg body weight showed dose-dependent, sex-related, proliferative and metaplastic alterations in the upper and lower respiratory tract within one year. The biologic behavior of the induced lung tumors is very similar to that of human lung adenocarcinomas.
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