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. 1961 Oct;17(2):278-85.
doi: 10.1111/j.1476-5381.1961.tb01289.x.

Effect of 5-hydroxytryptamine on the respiration of excised lamellibranch gill

K E MOORE, A S MILTON, R E GOSSELIN

Effect of 5-hydroxytryptamine on the respiration of excised lamellibranch gill

K E MOORE et al. Br J Pharmacol Chemother. 1961 Oct.

Abstract

5-Hydroxytryptamine, but not acetylcholine or catecholamines, stimulated the endogenous respiration of the excised gills of Modiolus demissus and mytilus edulis. Respiratory stimulation by 5-hydroxytryptophan is presumed to have occurred only after it had been decarboxylated to 5-hydroxytryptamine. 2-Bromolysergic acid diethylamide inhibited the effect of 5-hydroxytryptamine, while lysergic acid diethylamide mimicked it. The glycogen that was degraded during incubation of the gill cannot account for all of the oxygen that was consumed, indicating that some other substrate within the gill was also oxidized. That the metabolic actions of 5-hydroxytryptamine may be related to its cilio-acceleratory activity is discussed.

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