Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Nov 1;146(5):1455-60.
doi: 10.1084/jem.146.5.1455.

Occurrence of restricted suppressor T-cell activity in man

M A Bean, Y Kodera, K B Cummings, B R Bloom

Occurrence of restricted suppressor T-cell activity in man

M A Bean et al. J Exp Med. .

Abstract

Blood leukocytes from an immunologically hyporesponsive patient with urinary bladder carcinoma were found to be deficient in their ability to stimulate 3 of 27 responder leukocyte preparations from normal individuals in one-way mixed leukocyte culture (MLC). The patient's T-depleted leukocytes, however, functioned adequately as stimulator cells. T-enriched lymphocytes from this patient suppressed the MLC responsiveness of those three normals but not the responsiveness of other normals. The patient's cells suppressed the MLC responsiveness of only one of each of the parents of two of the normals who could be suppressed by the patient's leukocytes suggesting a possible genetic restriction to this suppressor cell activity.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Clin Invest. 1976 Feb;57(2):319-28 - PubMed
    1. J Exp Med. 1976 Sep 1;144(3):685-98 - PubMed
    1. J Exp Med. 1976 Sep 1;144(3):713-25 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Aug;73(8):2890-4 - PubMed
    1. Clin Immunol Immunopathol. 1976 Sep;6(2):192-9 - PubMed

Publication types