Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1992 Oct;14(5):376-9.
doi: 10.1097/00007691-199210000-00006.

Changes in unbound and total valproic acid concentrations after replacement of carbamazepine with oxcarbazepine

D Battino  1 , D Croci, T Granata, G Bernardi, G Monza
Affiliations
Comparative Study

Changes in unbound and total valproic acid concentrations after replacement of carbamazepine with oxcarbazepine

D Battino et al. Ther Drug Monit. 1992 Oct.

Abstract

Total and free valproic acid (VPA) concentrations were measured in patients switched from a combined VPA and carbamazepine (CBZ) to a combined VPA and oxcarbazepine (OXC) therapy, both administered in individualized daily doses. Four young epileptic patients (13-17 years old) were studied for a 12-week period, total and free VPA concentrations being analyzed just before and 4 h after the morning dose, at the end of VPA and CBZ therapy, and 2 and 10 weeks after CBZ was replaced by OXC. The expected increase in the level/dose (L/D) ratio of total VPA observed at the end of the study was preceded by a clear-cut increase in the L/D ratio of free VPA, which led to VPA-related side effects and required the retitration of VPA daily doses.

PubMed Disclaimer

Publication types