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. 1961 Oct;4(4):388-400.

Studies on the mechanism of hypersensitivity phenomena. IV. An isometric smooth muscle assay system

H G RANDALL, S L TALBOT, H C NEU, A G OSLER

Studies on the mechanism of hypersensitivity phenomena. IV. An isometric smooth muscle assay system

H G RANDALL et al. Immunology. 1961 Oct.

Abstract

An isometric system for the assay of smooth muscle contraction is described. Studies of the nature of the response of this tissue to histamine, anaphylatoxin and specific antigen indicate important differences with respect to length of latent period and the effect of repetitive stimuli. Data are presented on the effect of variation in the calcium concentration on the responsiveness to histamine and antigen.

Regional variability in the responsiveness of guinea-pig small intestine to various stimuli has been studied. Data are presented which indicate that the rate of increase of the response to antigen, and the maximal force of the response to antigen, are temperature dependent. The responses to antigen are not significantly different after prior exposure to acetylcholine, serotonin, histamine, or potassium ions.

Contractions induced by potassium chloride are followed by markedly diminished responses to rat serum anaphylatoxin.

Further data are provided on the parallelism between C′3 utilization and formation of anaphylatoxin from rat serum.

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