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. 1977 Oct;74(10):4306-10.
doi: 10.1073/pnas.74.10.4306.

Oligomycin-dependent ionophoric protein subunit of mitochondrial adenosinetriphosphatase

R S Criddle, L Packer, P Shieh

Oligomycin-dependent ionophoric protein subunit of mitochondrial adenosinetriphosphatase

R S Criddle et al. Proc Natl Acad Sci U S A. 1977 Oct.

Abstract

A proteolipid isolated from yeast mitochondrial adenosinetriphosphatase (subunit 9) (ATP phosphohydrolase; EC 3.6.1.3) by chloroform/methanol extraction has been shown to discharge photo-induced potentials across a planar phospholipid membrane containing bacteriorhodopsin. Oligomycin, a specific inhibitor of oxidative phosphorylation which binds to this protein, allows the potential gradient to be reestablished. When proteolipid was isolated from an oligomycin-resistant strain, ionophoric activity was still obtained but the effect was not reversed by oligomycin. These studies suggest that the hydrophobic subunit-9 polypeptide is the ionophoric component linking ATP synthesis (hydrolysis) with proton translocation.

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References

    1. J Biol Chem. 1975 Sep 25;250(18):7533-4 - PubMed
    1. J Bacteriol. 1975 Nov;124(2):870-83 - PubMed
    1. J Membr Biol. 1975 Dec 4;25(1-2):65-74 - PubMed
    1. J Biol Chem. 1976 Jul 10;251(13):4147-54 - PubMed
    1. FEBS Lett. 1976 Jun 15;65(3):391-5 - PubMed

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