Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Nov;74(11):4919-23.
doi: 10.1073/pnas.74.11.4919.

F1-ATPase-catalyzed synthesis of ATP from oleoylphosphate and ADP

R Johnston, R S Criddle

F1-ATPase-catalyzed synthesis of ATP from oleoylphosphate and ADP

R Johnston et al. Proc Natl Acad Sci U S A. 1977 Nov.

Abstract

Purified preparations of F1-ATPase (ATP phosphohydrolase; EC 3.6.1.3) isolated from yeast mitochondria catalyze the reaction of oleoylphosphate with ADP to yield ATP and oleic acid. Formation of ATP is specifically inhibited by the F1-ATPase inhibitor 1799 and by dinitrophenol. In the presence of F1, dinitrophenol "uncouples" the synthase reaction by causing rapid hydrolysis of oleoylphosphate without ATP formation. It is proposed that this F1 catalyzed ATP synthesis reaction corresponds to the terminal chemical step in oxidative phosphorylation.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. J Biol Chem. 1975 Dec 10;250(23):9121-9 - PubMed
    1. J Biol Chem. 1958 Dec;233(6):1574-7 - PubMed
    1. Biochem J. 1976 Dec 15;160(3):809-12 - PubMed
    1. Biochem J. 1977 Mar 15;162(3):575-80 - PubMed
    1. Arch Biochem Biophys. 1977 Aug;182(2):587-600 - PubMed

MeSH terms