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Clinical Trial
. 1992 Sep;3(8):659-60.
doi: 10.1093/oxfordjournals.annonc.a058298.

Multicenter phase II trial of brequinar sodium in patients with advanced melanoma

R Natale  1 , R Wheeler, M Moore, B Dallaire, W Lynch, R Carlson, A Grillo-Lopez, J Gyves
Affiliations
Free article
Clinical Trial

Multicenter phase II trial of brequinar sodium in patients with advanced melanoma

R Natale et al. Ann Oncol. 1992 Sep.
Free article

Abstract

Seventeen patients with advanced melanoma and no prior exposure to chemotherapy were treated with brequinar sodium as first-line chemotherapy. Brequinar was given at a median weekly dose of 1200 mg/m2 intravenously. In 14 patients evaluable for efficacy, there were no objective responses. The toxicity was moderate. We conclude that, at this dose and schedule, brequinar has no activity in advanced melanoma.

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