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. 2003 Sep 19;301(5640):1731-3.
doi: 10.1126/science.1086016.

Demography of dietary restriction and death in Drosophila

William Mair  1 , Patrick Goymer, Scott D Pletcher, Linda Partridge
Affiliations

Demography of dietary restriction and death in Drosophila

William Mair et al. Science. .

Abstract

Dietary restriction (DR) increases life-span in organisms from yeast to mammals, presumably by slowing the accumulation of aging-related damage. Here we show that in Drosophila, DR extends life-span entirely by reducing the short-term risk of death. Two days after the application of DR at any age for the first time, previously fully fed flies are no more likely to die than flies of the same age that have been subjected to long-term DR. DR of mammals may also reduce short-term risk of death, and hence DR instigated at any age could generate a full reversal of mortality.

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Comment in

  • Aging. It's never too late.
    Vaupel JW, Carey JR, Christensen K. Vaupel JW, et al. Science. 2003 Sep 19;301(5640):1679-81. doi: 10.1126/science.1090529. Science. 2003. PMID: 14500969 Free PMC article.
  • Dietary restriction in Drosophila.
    Rauser CL, Mueller LD, Rose MR. Rauser CL, et al. Science. 2004 Mar 12;303(5664):1610-2; author reply 1610-2. doi: 10.1126/science.303.5664.1610c. Science. 2004. PMID: 15016980 No abstract available.

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