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Review
. 1992 Dec 11;1113(3-4):375-89.
doi: 10.1016/0304-4157(92)90007-w.

Spontaneous lipid transfer between organized lipid assemblies

R E Brown  1
Affiliations
Review

Spontaneous lipid transfer between organized lipid assemblies

R E Brown. Biochim Biophys Acta. .
No abstract available

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Figures

Fig. 1
Fig. 1
Models for spontaneous lipid transfer between membranes. Transferring lipids are depicted with filled headgroups. (A) In the monomer transfer model, individual lipid monomers desorb from donor surface and then diffuse through the bulk aqueous phase prior to incorporation into an acceptor surface. (B) In the transient collision model, the desorption of individual lipid monomers from the donor surface is enhanced by the apposition of hydrated donor and acceptor surfaces. Monomer diffusion occurs across the hydration barrier (approx. 1.5 nm) between the apposed surfaces. (C) In the ‘hemifusion’ model, direct contact between donor and acceptor surfaces permits mixing of the outer monolayer lipids by lateral diffusion.
Fig. 2
Fig. 2
Free energy diagram of fluorescent PC partitioning between liquid-crystalline PC small unilamellar vesicles and water. The upper schematic represents a phospholipid molecule desorbing from a phospholipid bilayer. In the energy diagram below, the length and direction of the arrows represent the absolute magnitudes of the energy components (reprinted with permission from Nichols [123], copyright 1985, American Chemical Society).
Fig. 3
Fig. 3
Energy diagram showing the effect of acceptor vesicle interaction on lipid monomer activation energy. In A, the free energy associated with lipid monomer desorption from the phospholipid bilayer into the aqueous phase is depicted. In B. the decrease in activation energy upon apposition of an acceptor vesicle is depicted. The free energy of interaction is the attractive energy imparted to the monomer by the acceptor vesicle. The vesicle-vesicle separation distance is assumed to be approximately that at which repulsive and attractive forces are equal (approx. 1.5 nm) (reprinted with permission from Jones and Thompson [108], copyright 1990, Amercian Chemical Society).
See this image and copyright information in PMC

References

    1. Brown RE. In: Subcellular Biochemistry. Hilderson HJ, editor. Vol. 16. Plenum Press; New York: 1990. pp. 333–363. - PubMed
    1. Bruckdorfer KR, Graham JM. In: Biological Membranes. Chapman D, Wallach D, editors. Vol. 13. Academic Press; London: 1976. pp. 103–152.
    1. Lange Y. In: Handbook of Lipid Research: The Physical Chemistry of Lipids. Small DM, editor. Vol. 4. Plenum Press; New York: 1986. pp. 538–549.
    1. Sleight RG. Annu Rev Physiol. 1987;49:193–208. - PubMed
    1. Dawidowicz EA. Curr Top Membr Transp. 1987;29:175–202.

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