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. 2003 Sep;165(1):399-409.
doi: 10.1093/genetics/165.1.399.

Genetic control of developmental changes induced by disruption of Arabidopsis histone deacetylase 1 (AtHD1) expression

Lu Tian  1 , Jianlin Wang, M Paulus Fong, Meng Chen, Hongbin Cao, Stanton B Gelvin, Z Jeffrey Chen
Affiliations

Genetic control of developmental changes induced by disruption of Arabidopsis histone deacetylase 1 (AtHD1) expression

Lu Tian et al. Genetics. 2003 Sep.

Abstract

Little is known about the role of genetic and epigenetic control in the spatial and temporal regulation of plant development. Overexpressing antisense Arabidopsis thaliana HD1 (AtHD1) encoding a putative major histone deacetylase induces pleiotropic effects on plant growth and development. It is unclear whether the developmental abnormalities are caused by a defective AtHD1 or related homologs and are heritable in selfing progeny. We isolated a stable antisense AtHD1 (CASH) transgenic line and a T-DNA insertion line in exon 2 of AtHD1, resulting in a null allele (athd1-t1). Both athd1-t1 and CASH lines display increased levels of histone acetylation and similar developmental abnormalities, which are heritable in the presence of antisense AtHD1 or in the progeny of homozygous (athd1-t1/athd1-t1) plants. Furthermore, when the athd1-t1/athd1-t1 plants are crossed to wild-type plants, the pleiotropic developmental abnormalities are immediately restored in the F(1) hybrids, which correlates with AtHD1 expression and reduction of histone H4 Lys12 acetylation. Unlike the situation with the stable code of DNA and histone methylation, developmental changes induced by histone deacetylase defects are immediately reversible, probably through the restoration of a reversible histone acetylation code needed for the normal control of gene regulation and development.

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References

    1. Plant J. 2000 Apr;22(1):19-27 - PubMed
    1. Mol Gen Genet. 1998 May;258(3):288-96 - PubMed
    1. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13708-13 - PubMed
    1. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14178-82 - PubMed
    1. Mol Cell. 2000 Oct;6(4):791-802 - PubMed

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