Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Oct;47(10):3323-5.
doi: 10.1128/AAC.47.10.3323-3325.2003.

DNA gyrase and topoisomerase IV mutations in clinical isolates of Ureaplasma spp. and Mycoplasma hominis resistant to fluoroquinolones

Affiliations

DNA gyrase and topoisomerase IV mutations in clinical isolates of Ureaplasma spp. and Mycoplasma hominis resistant to fluoroquinolones

C M Bébéar et al. Antimicrob Agents Chemother. 2003 Oct.

Abstract

Twelve clinical isolates of Ureaplasma spp. and one isolate of Mycoplasma hominis were examined for resistance to fluoroquinolones. Previously described mutations at positions 83 and 95 in GyrA (Escherichia coli numbering) and positions 80 and 87 in ParC were found. Unusual alterations were described at positions ParC 123 and 134.

PubMed Disclaimer

References

    1. Abele-Horn, M., C. Wolff, P. Dressel, F. Pfaff, and A. Zimmermann. 1997. Association of Ureaplasma urealyticum biovars with clinical outcome for neonates, obstetric patients, and gynecological patients with pelvic inflammatory disease. J. Clin. Microbiol. 35:1199-1202. - PMC - PubMed
    1. Abraham, B., C. Leclercq, C. Bébéar, H. Renaudin, and F. Janbon. 2001. Septic arthritis due to Ureaplasma urealyticum: concerning one case. Med. Mal. Infect. 31:453-454.
    1. Bast, D. J., D. E. Low, C. L. Duncan, L. Kilburn, L. A. Mandell, R. J. Davidson, and J. C. S. Deazavedo. 2000. Fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae: contributions of type II topoisomerase mutations and efflux to levels of resistance. Antimicrob. Agents Chemother. 44:3049-3054. - PMC - PubMed
    1. Bébéar, C. M., H. Renaudin, A. Charron, J. M. Bové, C. Bébéar, and J. Renaudin. 1998. Alterations in topoisomerase IV and DNA gyrase in quinolone-resistant mutants of Mycoplasma hominis obtained in vitro. Antimicrob. Agents Chemother. 42:2304-2311. - PMC - PubMed
    1. Bébéar, C. M., H. Renaudin, A. Charron, D. Gruson, M. Lefrançois, and C. Bébéar. 2000. In vitro activity of trovafloxacin compared to those of five antimicrobials against Mycoplasma hominis and Ureaplasma urealyticum fluoroquinolone-resistant isolates that have been genetically characterized. Antimicrob. Agents Chemother. 44:2557-2560. - PMC - PubMed

LinkOut - more resources