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Comparative Study
. 2003 Oct;47(10):3339-42.
doi: 10.1128/AAC.47.10.3339-3342.2003.

Effects of lipid-based oral formulations on plasma and tissue amphotericin B concentrations and renal toxicity in male rats

Verica Risovic  1 , Michael Boyd, Eugene Choo, Kishor M Wasan
Affiliations
Comparative Study

Effects of lipid-based oral formulations on plasma and tissue amphotericin B concentrations and renal toxicity in male rats

Verica Risovic et al. Antimicrob Agents Chemother. 2003 Oct.

Abstract

The purpose of this study was to determine the effects of various lipid and mixed-micelle formulations on the oral absorption and renal toxicity of amphotericin B (AMB) in rats. The maximum concentration of AMB in plasma and the area under the concentration-time curve for 0 to 24 h for AMB were elevated in rats administered triglyceride (TG)-rich AMB formulations in comparison to those in rats given (i) AMB preformulated as a micelle containing sodium deoxycholate with sodium phosphate as a buffer (DOC-AMB), (ii) an AMB-lipid complex suspension, or (iii) AMB solubilized in methanol. Furthermore, our findings suggest that AMB incorporated into TG-based oral formulations has less renal toxicity than DOC-AMB.

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Figures

FIG. 1.
FIG. 1.
Plasma AMB concentration versus time curve on a log-linear graph following administrations by oral gavage of DOC-AMB (□), ABLC (◊), Intralipid-AMB at 50 mg of AMB/kg (○), and Peceol-AMB at 50 (▵) and 5 (⊞) mg of AMB/kg. Values are expressed as means ± standard deviations (six rats per treatment group).
See this image and copyright information in PMC

References

    1. Blom, G. 1958. Statistical estimates and transformed beta variables, p. 1-58. John Wiley and Sons, Inc., New York, N.Y.
    1. Chavanet, P., V. Joly, D. Rigaud, J. Bolard, C. Carbon, and P. Yeni. 1994. Influence of diet on experimental toxicity of amphotericin B deoxycholate. Antimicrob. Agents Chemother. 38:963-968. - PMC - PubMed
    1. Dangi, J. S., S. P. Vyas, and V. K. Dixit. 1998. Effects of various lipid-bile salt mixed micelles on the intestinal absorption of amphotericin-B in rat. Drug Dev. Ind. Pharm. 24:631-635. - PubMed
    1. Egito, E. S. T., I. B. Araujo, P. G. Bolivar, L. Damasceno, and J. C. Price. 2002. Amphotericin B/emulsion admixture interactions: an approach concerning the reduction of amphotericin B toxicity. J. Pharm. Sci. 91:2354-2366. - PubMed
    1. Fagerholm, U., M. Johansson, and H. Lennernas. 1996. Comparison between permeability coefficients in rat and human jejunum. Pharm. Res. 13:1336-1342. - PubMed

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