Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Sep 24;290(12):1581-2.
doi: 10.1001/jama.290.12.1581.

APOE genotype and cerebral blood flow in healthy young individuals

APOE genotype and cerebral blood flow in healthy young individuals

Nikolaos Scarmeas et al. JAMA. .
No abstract available

PubMed Disclaimer

Figures

Figure
Figure
Resting Relative Cerebral Blood Flow (rCBF) in Individuals With and Without an Apolipoprotein ε4 Allele Three-dimensional brain-rendering representation of statistical parametric mapping. Areas of red depict areas in which mean resting rCBF is significantly (P<.05, Bonferroni corrected) different between individuals with and without an ε4 allele. The graphs plot the rCBF values for the 2 groups in regions in which differences were most significant—the left inferior temporal gyrus and the left insula. The values in parentheses in the graph panel labels are Talairach coordinates denoting the exact brain locations of the statistically significant areas.

References

    1. Small GW, Mazziotta JC, Collins MT, et al. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease. JAMA. 1995;273:942–947. - PubMed
    1. Reiman EM, Caselli RJ, Yun LS, et al. Preclinical evidence of Alzheimer’s disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med. 1996;334:752–758. - PubMed
    1. Arendt T, Schindler C, Bruckner MK, et al. Plastic neuronal remodeling is impaired in patients with Alzheimer’s disease carrying apolipoprotein epsilon 4 allele. J Neurosci. 1997;17:516–529. - PMC - PubMed
    1. Morishima-Kawashima M, Oshima N, Ogata H, et al. Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain. Am J Pathol. 2000;157:2093–2099. - PMC - PubMed
    1. Ghebremedhin E, Schultz C, Braak E, Braak H. High frequency of apolipoprotein E epsilon4 allele in young individuals with very mild Alzheimer’s disease-related neurofibrillary changes. Exp Neurol. 1998;153:152–155. - PubMed

Substances