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Clinical Trial
. 2003 Oct;87(10):1235-7.
doi: 10.1136/bjo.87.10.1235.

A randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis

N V Prajna  1 , R K John, P K Nirmalan, P Lalitha, M Srinivasan
Affiliations
Clinical Trial

A randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis

N V Prajna et al. Br J Ophthalmol. 2003 Oct.

Abstract

Aim: To compare 2% econazole and 5% natamycin in the management of fungal keratitis.

Methods: A randomised clinical trial was performed using 2% econazole or 5% natamycin as the two treatment arms on patients presenting with culture positive fungal keratitis to the cornea service at Aravind Eye Care System, Madurai, India.

Results: 116 patients were recruited, and 112 continued in the study. There were no significant differences between the two arms at baseline or for success (defined as a healed or healing ulcer) at final visit (p = 0.79).

Conclusions: 2% Econazole appears to be as effective as 5% natamycin for the management of fungal keratitis.

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Figures

Figure 1
Figure 1
Flow chart of the participation in the study.
Figure 2
Figure 2
Survival curves comparing 2% econazole and 5% natamycin for fungal keratitis.
See this image and copyright information in PMC

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