Comparative in-vitro activities of commonly available quinolones and other antibiotics on bacterial isolates in Ibadan, Nigeria
- PMID: 14510147
Comparative in-vitro activities of commonly available quinolones and other antibiotics on bacterial isolates in Ibadan, Nigeria
Abstract
The 4-quinolones, many of which are now available in Nigeria under different trade names, have a broad spectrum of activity. An evaluation is made of the comparative in-vitro activities of these quinolones and other antibiotics against 125 strains of bacteria commonly isolated from clinical specimens in University College Hospital, Ibadan, by using the Stroke's disc sensitivity method, and MIC estimation. The quinolones showed greater activity than the cephalosprins against Klebsiella spp., Proteus spp. and Escherichia coli, but were found to be equipotent against Pseudomonas spp. the MIC results revealed ciprofloxacin (Ciprotap) as the most active of the quinolones. Though some strains of Klebsiella spp. and Pseudomonas spp. were found to be resistant to all the antibiotics tested, majority of the strains of the gram-negative bacilli from clinical specimens were highly susceptible to all the quinolones. This emphasizes the need to monitor regularly the emergence of resistance associated with the use of antibiotics in the developing countries.
Similar articles
-
Plasmid determined resistance to quinolones in clinical isolates of Gram-negative bacilli.Afr J Med Med Sci. 2006 Dec;35(4):437-41. Afr J Med Med Sci. 2006. PMID: 17722809
-
[In vitro sensitivity of gram-negative bacteria isolated from urinary tract infections to various antibiotics].Mikrobiyol Bul. 1991 Jan;25(1):28-35. Mikrobiyol Bul. 1991. PMID: 1881356 Turkish.
-
Comparisons of parenteral broad-spectrum cephalosporins tested against bacterial isolates from pediatric patients: report from the SENTRY Antimicrobial Surveillance Program (1998-2004).Diagn Microbiol Infect Dis. 2007 Jan;57(1):109-16. doi: 10.1016/j.diagmicrobio.2006.06.011. Epub 2006 Aug 23. Diagn Microbiol Infect Dis. 2007. PMID: 16930923
-
Development of clinically important resistance to quinolones and other antibiotic groups.J Int Med Res. 1990;18 Suppl 4:27D-36D. J Int Med Res. 1990. PMID: 2282967 Review.
-
Quinolones: clinical use and formulary considerations.Adv Ther. 1998 Sep-Oct;15(5):277-87. Adv Ther. 1998. PMID: 10345149 Review.
Cited by
-
Carbapenem resistance associated with coliuria among outpatient and hospitalised urology patients.New Microbes New Infect. 2022 Aug 29;48:101019. doi: 10.1016/j.nmni.2022.101019. eCollection 2022 Jul. New Microbes New Infect. 2022. PMID: 36176538 Free PMC article.
-
Significant bacteriuria among asymptomatic antenatal clinic attendees in ibadan, Nigeria.Trop Med Health. 2011 Sep;39(3):73-6. doi: 10.2149/tmh.2011-02. Epub 2011 Sep 30. Trop Med Health. 2011. PMID: 22028612 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical
Miscellaneous