doi: 10.1021/np0301691.
Purification, structure determination, and antimicrobial activity of neutramycins B-G
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- PMID: 14510587
- DOI: 10.1021/np0301691
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Purification, structure determination, and antimicrobial activity of neutramycins B-G
J Nat Prod.
2003 Sep.
Abstract
Neutramycins B-G were purified from a historical sample of neutramycin in our antibiotic collection. The structures of the compounds were solved by 2D NMR spectroscopic analysis. Four of the compounds (2-5) are probable biosynthetic intermediates or shunt metabolites of neutramycin biosynthesis, while two (6, 7) are likely to be degradation products. Only one intermediate (5) showed weak Gram-positive activity.
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