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Multicenter Study
. 2003 Oct;58(10):1064-6.
doi: 10.1034/j.1398-9995.2003.00267.x.

Prevalence of asthma with aspirin hypersensitivity in the adult population of Poland

L Kasper  1 , K Sladek, M Duplaga, G Bochenek, J Liebhart, U Gladysz, J Malolepszy, A Szczeklik
Affiliations
Multicenter Study

Prevalence of asthma with aspirin hypersensitivity in the adult population of Poland

L Kasper et al. Allergy. 2003 Oct.

Abstract

Background: Acetylsalicylic acid (ASA) and other nonsteroid anti-inflammatory drugs (NSAIDs) are reported to account for 21-25% of all adverse drug reactions. Some asthmatics may react to ASA and other NSAIDs with acute bronchoconstriction, profuse rhinorrhea and skin flushing. This is a distinct clinical syndrome called aspirin-induced asthma (AIA). The prevalence of AIA among asthmatic patients in Poland has not been previously assessed.

Methods: A questionnaire survey of 12,970 adults of both sexes, randomly selected from the population of Poland.

Results: The prevalence of AIA in the general population of Poland was estimated as 0.6%. Thirty patients (4.3%; 95% CI: 2.8-5.8) of 703 asthmatics (5.4% of general population) reported symptoms attesting to hypersensitivity to aspirin. In 27% of them the reactions were precipitated by aspirin, whereas in the remaining subjects by other NSAIDs.

Conclusions: The prevalence of AIA in Poland is 4.3%, being somewhat lower than in Finland and Australia, where it was recently reported to account for 8.8 and 10.9% of the adult asthmatics, respectively. These figures indicate that aspirin hypersensitivity might be a significant community problem.

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