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. 2003 Aug;6(4):322-4.
doi: 10.1375/136905203322296692.

Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels

Marian Beekman  1 , Bastiaan T Heijmans, Nicholas G Martin, John B Whitfield, Nancy L Pedersen, Ulf DeFaire, Harold Snieder, Nico Lakenberg, Peter de Knijff, Rune R Frants, Gert Jan B van Ommen, Cornelis Kluft, George P Vogler, P Eline Slagboom, Dorret I Boomsma
Affiliations

Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels

Marian Beekman et al. Twin Res. 2003 Aug.

Abstract

Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.

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