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. 2003 Oct 10;310(1):176-81.
doi: 10.1016/j.bbrc.2003.08.135.

A mutation in the gene involved in sister chromatid separation causes a defect in nuclear mRNA export in fission yeast

Abul Kalam Azad  1 , Takashi Ideue, Yasumi Ohshima, Tokio Tani
Affiliations

A mutation in the gene involved in sister chromatid separation causes a defect in nuclear mRNA export in fission yeast

Abul Kalam Azad et al. Biochem Biophys Res Commun. .

Abstract

Fission yeast ptr4-1 is one of the mRNA transport mutants that accumulate poly(A)(+) RNA in the nuclei at the nonpermissive temperature. We cloned the ptr4(+) gene and found that it is identical with the cut1(+) gene essential for chromosome segregation during mitosis. ptr4/cut1 has no defects in nucleocytoplasmic transport of a protein, indicative of a specific blockage of mRNA export by this mutation. A mutant of Cut2p cooperating with Cut1p in sister chromatid separation also showed defective mRNA export at the nonpermissive temperature. Our results suggest a novel linkage between the cell division cycle and nuclear mRNA export in eukaryotic cells.

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