Task relevance enhances early transient and late slow-wave activity of distributed cortical sources

Abstract

The primary purpose of these studies was to link together concepts related to attention/working memory and feedforward/feedback activity using MEG response profiles obtained in humans. Similar to recent studies of attention in monkeys, we show early "spike-like" activity (<200 ms poststimulus), most likely reflecting an early transient excitatory response mixed with feedback influences, followed by "slow-wave" activity (>200 ms poststimulus) in MEG cortical response profiles evoked by a visual working memory task. We experimentally dissociated the early transient activity from the later sustained activity (predominantly feedback) by conducting an auditory size classification task. Words, representing common objects, evoked activity in occipital cortex (presumably due to imagery) even though visual stimuli were not present in this task. The initial "spike" was absent from the response profile obtained from occipital cortex, leaving only "slow-wave" activity, thereby allowing us to characterize or profile feedback activity in this situation. Attention or task relevance enhanced the initial "spike" and "slow-wave" activity in visually responsive areas. Prefrontal activity, along the superior frontal sulcus, evoked by the working memory task, was active later in time than initial activity in visual cortex and later than the earliest effect of attention modulation in visual cortex.