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Clinical Trial
. 2003 Sep;143(3):399-401.
doi: 10.1067/s0022-3476(03)00388-3.

Naproxen as an alternative to aspirin for the treatment of arthritis of rheumatic fever: a randomized trial

Philip J Hashkes  1 , Tsivia Tauber, Eli Somekh, Riva Brik, Judith Barash, Masza Mukamel, Liora Harel, Abraham Lorber, Matityahu Berkovitch, Yosef Uziel; Pediatric Rheumatlogy Study Group of Israel
Affiliations
Clinical Trial

Naproxen as an alternative to aspirin for the treatment of arthritis of rheumatic fever: a randomized trial

Philip J Hashkes et al. J Pediatr. 2003 Sep.

Abstract

We performed a prospective, randomized, open-label equivalence study comparing the use of naproxen to aspirin in 33 patients with rheumatic fever. The mean time until resolution of arthritis was 2.9+/-2.9 days in both groups. Liver enzyme elevations were more frequent in the aspirin group (P=.002). We conclude that naproxen is as effective, is easier to use, and is safer than aspirin in the treatment of the arthritis of rheumatic fever.

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