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. 2003 Sep;9(9):1163-7.
doi: 10.3201/eid0909.030367.

Microbiologic characteristics, serologic responses, and clinical manifestations in severe acute respiratory syndrome, Taiwan

Po-Ren Hsueh  1 , Cheng-Hsiang Hsiao, Shiou-Hwei Yeh, Wei-Kung Wang, Pei-Jer Chen, Jin-Town Wang, Shan-Chwen Chang, Chuan-Liang Kao, Pan-Chyr Yang; SARS Research Group of National Taiwan University College of Medicine and National Taiwan University Hospital
Affiliations

Microbiologic characteristics, serologic responses, and clinical manifestations in severe acute respiratory syndrome, Taiwan

Po-Ren Hsueh et al. Emerg Infect Dis. 2003 Sep.

Abstract

The genome of one Taiwanese severe acute respiratory syndrome-associated coronavirus (SARS-CoV) strain (TW1) was 29,729 nt in length. Viral RNA may persist for some time in patients who seroconvert, and some patients may lack an antibody response (immunoglobulin G) to SARS-CoV <21 days after illness onset. An upsurge of antibody response was associated with the aggravation of respiratory failure.

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Figures

Figure 1
Figure 1
Thin-section electron micrograph of severe acute respiratory syndrome-associated coronavirus grown in Vero E6 cells. Panel A shows extracellular viral particles (arrow) lining the surface of the plasma membrane. Some spikes projecting from the envelope of the virus are seen. Panel B shows numerous spherical coronavirus particles (arrow) within dilated cytoplasmic vacuoles (arrowhead).
Figure 2
Figure 2
Timelines of positive reverse-transcription polymerase chain reaction, antibody responses and treatment regimens (ribavirin, corticosteroid, and intravenous immunoglobulin) after onset of disease in seven patients with severe acute respiratory syndrome. Panels A–C indicate patients 1, 2, and 4.
See this image and copyright information in PMC

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