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Review
. 2003 Sep;95(6):329-33.
doi: 10.1016/s0248-4900(03)00081-9.

Mesial temporal lobe epilepsy: a pathological replay of developmental mechanisms?

Ivan Cohen  1 , Vincent Navarro, Caroline Le Duigou, Richard Miles
Affiliations
Review

Mesial temporal lobe epilepsy: a pathological replay of developmental mechanisms?

Ivan Cohen et al. Biol Cell. 2003 Sep.

Abstract

Focal epilepsies of the mesial temporal lobe are often associated with a hippocampal sclerosis. Changes in Cl homeostasis and GABAergic signalling in downstream regions, may contribute to the human pathology. A review of changes in cellular and synaptic function and connectivity after de-afferentation suggests this epileptic syndrome may involve a pathological replay of developmental mechanisms.

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