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Comparative Study
. 2003 Oct 6;89(7):1266-9.
doi: 10.1038/sj.bjc.6601241.

Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma

J P Kallio  1 , P Hirvikoski, H Helin, P Kellokumpu-Lehtinen, T Luukkaala, T L J Tammela, P M Martikainen
Affiliations
Comparative Study

Membranous location of EGFR immunostaining is associated with good prognosis in renal cell carcinoma

J P Kallio et al. Br J Cancer. .

Abstract

Epidermal growth factor receptor (EGFR) is a key factor in tumorigenesis. The association between EGFR expression and prognosis in renal cell carcinoma (RCC) is not clear. In our study of 134 RCCs, the cellular location of immunostaining was evaluated and patients with EGFR-positive tumours with prominent membranous staining had a good prognosis. Their overall survival was significantly longer (P=0.004) than that of patients with either EGFR-negative tumours or with mainly cytoplasmic staining. However, further studies on the different EGFR expression patterns in RCC are needed to clarify their role in the progression of the disease.

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Figures

Figure 1
Figure 1
Membranous (A) and cytoplasmic (B) EGFR staining of two cases of RCC and the corresponding morphology (C, D) in haematoxylin and eosin staining. Placental control of EGFR staining is shown in the inset in B.
Figure 2
Figure 2
Survival of RCC patients and its correlation with EGFR localisation. Group 1: no staining, group 2: prominent membranous staining and group 3: predominantly cytoplasmic staining.
See this image and copyright information in PMC

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