[Antihistamine drugs in the treatment of allergic skin diseases]

Abstract

Antihistaminic therapy is widely used in the treatment of allergic dermatoses. Second generation antihistamines due to their pharmacokinetic mechanism depending on the wide extra-receptor anti-inflammatory and anti-allergic actions are used in the treatment of diseases, in which the main pathogenetic role is played by various allergic mechanisms and inflammatory cellular processes. The modern views on etiopathogenesis and antihistaminic treatment of allergic skin diseases are presented in this paper. The course of allergic inflammation, role of histamine and its receptors, taking into consideration the biological effects of their suppression and influence on the course of early and late phase of allergic reaction, are discussed. A review of classical and second generation antihistamines has been done, taking into account their usefulness in the treatment of acute and chronic urticaria, angioedema, atopic dermatitis, different forms of eczema and various drug-induced reactions.